greetings guys, it me again for another quest of seeking enlightening advice

..im really enjoying this game and as i level, im afraid that one day i realize i must have done these or that before actually moving to a higher level or moving to the next region. now im currently at avila volcano, and im well aware that lvl 45 onward is gonna be tougher. now here are my questions, please bear with me:
1. should i participate always in arena? (with all available classes i.e.)
2. do i need to raise all my fame? like region especially the ones from Aven? i am atm gaining fame from pyrowind for my tank (knight)
if so..which is better? gathering matts for the fame or turning in the monster essences i collected?
3. should i level all my available classes equally?
clearly i just want know a "path" in playing EE, i know we cant take all but what do you guys suggest? thank you